Requirements for the inhibition of sodium and potassium ion-transporting adenosine triphosphatase by adriamycin.
نویسندگان
چکیده
Doublet, M. 0. & Olornucki, A. (1975) Eur. J. Biochem. 59, 175-183 Flynn, T. G., Shires, J. & Wilton. D. W. (1975) J. Eiol. Chem. 250, 2933-2940 Sheaff, C. M. & Doughty, C. C. (1976) J . Biol. Chem. 251,26962702 Thoai, N . V., Huc, C., Pho, D. B. & Olornucki, A. (1969) Biochim. Eiophys. Acta 191,46-57 Toews, C. J. (1967) Biochem. J. 105, 1067-1073 Wratten, C. C. & Cleland, W. W. (1963) Biochemistry 2, 935-941
منابع مشابه
Cardiac sodium, potassium-adenosine triphosphatase as a possible site of adriamycin-induced cardiotoxicity.
Adriamycin ws tested as a possible inhibitor of cardiac sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase). At concentrations of 10(-4) M and lower, Adriamycin had no effect upon either ouabain-sensitive (Na-K-ATPase) or ouabain-insensitive adenosine triphosphatase activity in homogenates and microsomal fractions of cardiac tissue from several different species. Adriamycin inhibi...
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Physiological ligands of (sodium-potassium)-dependent adenosine triphosphatase influenced the sensitivity of the enzyme to the inhibitor, ouabain. Phosphorylation of the native enzyme is accelerated by sodium ions, while potassium ions accelerate dephosphorylation. Exposure of the phosphoenzyme to ouabain slowed its turnover and rendered it insensitive to potassium ion. This action of ouabain d...
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In order to characterize a step in the reaction sequence of sodium and potassium ion-dependent adenosine triphosphatase (EC 3.6.1.3), the binding of radioactive adenosine triphosphate to kidney cell membranes was estimated by flow dialysis in the presence of a chelator of divalent cations, which prevented hydrolysis of the adenosine triphosphate. Adenosine triphosphate was bound to a single sit...
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Membrane transport may be effected by specific enzymatic systems. In a search for an enzymatic basis for sodium transport, Skou discovered an adenosine triphosphatase activity in particles from crab nerve which required both sodium and potassium ions together (1, 2). A similar activity was later identified in broken erythrocyte membranes as a part of the active transport system for sodium and p...
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In plasma membranes of intact cells an enzymatic pump actively transports sodium ions inward and potassium ions outward. In preparations of broken membranes it appears as an adenosine triphosphatase dependent on magnesium, sodium, and potassium ions together. In this adenosine triphosphatase a phosphorylated intermediate is formed from adenosine triphosphate in the presence of sodium ions and i...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 6 5 شماره
صفحات -
تاریخ انتشار 1978